Key result
Serology and valve PCR identify Bartonella species as culprits in culture-negative endocarditis cases.
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Two cases of bartonella endocarditis are described: one in a 55 year old homeless alcoholic man, caused by Bartonella quintana; the other in a 41 year old male with a history of exposure to cat fleas, caused by B henselae. Serological testing and polymerase chain reaction of the excised valves were used to identify the organisms. False positive serology for chlamydia was detected in one case.
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Breathnach et al. (1997) studied this question. Serological testing and polymerase chain reaction of excised valves identified Bartonella quintana and Bartonella henselae as the causes of culture-negative endocarditis in two adult men.
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