Open-source library of tissue engineering scaffolds

An open-source library of tissue engineering scaffolds focused on multi-scale and multi-material additive manufacturing is presented and documented with design maps. • The OS library of tissue engineering scaffolds applies design for additive manufacturing strategies, includes systematic variations and is documented with characterization maps, which facilitates applicability and materials and printing technology selection tasks. • It constitutes the first open-source library of tissue engineering scaffolds implemented with FAIR data principles in mind and shared as a collection of open-source geometries through remarkable open-science networks and co-creation environments. • The designed scaffolds include periodic and functionally-graded lattices, as well as more advanced multiscale, fractal and multimaterial constructs for emulating the intricate cellular microenvironments present in human tissues. • The OS library is already proving highly effective and practical for systematically and comparably evaluating the performance and limits of materials and technologies currently under development. Tissue engineering as a field may benefit from progressively implementing and spreading the use of standards, conceived to support the repeatability, replicability and efficient comparing of research results among experts in the field worldwide. Considering that scaffolds play a fundamental role in many tissue engineering strategies, it would be interesting to count with an internationally accepted set of geometries, acting as a library of lattices, porous materials and scaffolding structures, which could be employed for comparative purposes among materials and manufacturing technologies under development. To this end, an open-source library of tissue engineering scaffolds has been implemented. This library stands out for providing a comprehensive collection of scaffolds blueprints, designed considering the specific features of most additive manufacturing technologies applicable to tissue engineering and biofabrication. Besides, the library has been developed focusing on FAIR data principles along the development, for promoting: Findability, Accessibility, Interoperability and Reusability. The scaffolds are shared as open-source medical devices with the necessary documentation for facilitating their application. Similar initiatives may be synergically integrated towards an ISO standard on tissue engineering scaffolds.