January 1, 2005Hypertension ResearchOpen Access

Do Eicosapentaenoic Acid Supplements Attenuate Age-Related Increases in Arterial Stiffness in Patients with Dyslipidemia ?: A Preliminary Study

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Why the study?

Does eicosapentaenoic acid supplementation attenuate age-related increases in arterial stiffness in patients with dyslipidemia?

Population

84 patients with dyslipidemia, mean age ~64-65, Japanese cohort. Key exclusions: ABI <0.95, atrial…

Comparison

Eicosapentaenoic acid supplements 1,800 mg/day… vs Diet therapy in consultation with a nutritionist…

Design

Cohort, Quasi-randomized by birth month., Open-labeled

Follow-up

12 months

Authors

HTHirofumi TomiyamaPreventive Cardiology KTKenji TakazawaAsahikawa Medical College Hospital SOShinichi OsaTokyo Medical University

Discussion

Member takes

Implication

EPA may attenuate stiffness progression in dyslipidemia; hypothesis-generating and should not change practice without randomized confirmation.

Structured PICO

Does eicosapentaenoic acid supplementation attenuate age-related increases in arterial stiffness in patients with dyslipidemia?

Population

84 patients with dyslipidemia (total cholesterol >220 mg/dl and/or triglycerides >150 mg/dl despite treatment with statins and/or diet therapy for >6 months), mean age ~64-65, Japanese cohort. Key exclusions: ABI <0.95, atrial fibrillation, valvular heart disease, heart failure >NYHA class II, aortic aneurysm or dissection, serum creatinine ≥176.8 μmol/l.

Intervention

Eicosapentaenoic acid (EPA) supplements 1,800 mg/day for 12 months.

Comparator

Diet therapy in consultation with a nutritionist (according to Japan Atherosclerotic Society guidelines) for 12 months.

Outcome

Change in brachial-ankle pulse wave velocity (baPWV) over 12 months.surrogate

Eicosapentaenoic acid supplements (1,800 mg/day) may attenuate age-related increases in arterial stiffness in patients with dyslipidemia.

Limitations

Not fully randomized (allocation by birth month, non-consecutive enrollment)
Exclusion of approximately 12% of subjects due to large blood pressure fluctuations
Small sample size
Non-compliance with diet therapy in the control group

Cite This Study

Tomiyama et al. (2005) studied this question.

synapsesocial.com/papers/6a760e2d1ce449dc427086aa https://doi.org/10.1291/hypres.28.651

Topics

Lipid management

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Implication

EPA may attenuate stiffness progression in dyslipidemia; hypothesis-generating and should not change practice without randomized confirmation.

Do Eicosapentaenoic Acid Supplements Attenuate Age-Related Increases in Arterial Stiffness in Patients with Dyslipidemia ?: A Preliminary Study

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Do Eicosapentaenoic Acid Supplements Attenuate Age-Related Increases in Arterial Stiffness in Patients with Dyslipidemia ?: A Preliminary Study

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider