SINCE the earliest attempts were made to cultivate fungi on synthetic nutrient media, cases have been met with in which certain fungi were unable to grow in such media in the absence of small amounts of extracts prepared from natural products. The best known instance of this difficulty of culture is that of ordinary yeast, S. cerevisiae, which has been shown to need the presence of a small quantity of " bios " to enable healthy growth to take place on salt-sugar media. The nature of " bios " remains undetermined, although the problem has engaged the attention of many workers for some 30 years.
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Buston et al. (1931) studied this question.