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Multivalent design of antibacterials. Cationic charge and lipophilicity are major determinants of antibacterial activity in antimicrobial peptides that contain a high population of the amino acids Trp (W) and Arg (R). We show here that multivalent display of the RW dipeptide pharmacophore enhances antibacterial activity and membrane selectivity.
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Liu et al. (2007) studied this question.
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