Over the past 20 years the understanding of human leukocyte antigen (HLA) diversity and the impact of HLA matching on unrelated donor hematopoietic stem cell transplantation (HSCT) outcomes have evolved greatly. The National Marrow Donor Program (NMDP) has been intimately involved in monitoring, developing, and applying new methodologies for HLA testing, data capture techniques, and data representation methods to ensure that HLA typing of newly registered potential volunteer HSC donors and donors identified as potential matches is of the highest quality and accuracy for the benefit of searching patients.
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Spellman et al. (2008) studied this question.
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