The Effect of Advanced Maternal Age on Embryo Morphokinetics

PURPOSE To compare the morphokinetic parameters of preimplantation development between embryos of women of advanced maternal age (AMA) and young women. METHODS Time-lapse microscopy was used to compare morphokinetic variables between 495 embryos of AMA women ≥ age 42 years and 653 embryos of young patients (0.05). CONCLUSIONS While early morphokinetic parameters do not reflect dynamics unique to embryos of older women, a tendency towards developmental arrest was observed, which would likely be even more pronounced at later stages of development.