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The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a prototypical metabolic nuclear receptor that acts as a lipid sensor, integrating the homeostatic control of energy, lipid, and glucose metabolism. This perspective will highlight three lines of evidence which place PPAR-gamma as a key player in a feed-forward pathway favoring differentiation and energy storage by adipocytes.
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Auwerx et al. (2003) studied this question.
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