The effect of Venoruton on the symptoms and microcirculation was investigated in an open randomised placebo controlled study involving 35 patients with chronic venous hypertension. Treatment was for 6 weeks. There was a significant symptomatic relief (ache, cramps, skin irritation and swelling) according to an analogue scale line score in the active treatment group, but not in the placebo group. The symptomatic relief in this group was associated with a reduction in leg volume ( p < 0.5), resting and standing skin blood flow ( p < 0.05), restoration of the venoarteriolar reflex, a decrease in transcutaneous PO 2 ( p < 0.01) an increase in PO 2 ( p < 0.05). These parameters did not change in the placebo group. The results of this study demonstrate that Venoruton therapy has a marked effect on the microcirculation and indicate possible mechanisms of the relief of symptoms.
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Belcaro et al. (1989) studied this question.
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