The dissolution behavior and the solubility parameters of cefalexin powders of different crystallinity were determined. The maximum concentration of cefalexin in water 35°C increased with decreasing the crystallinity. Partial solubility parameters of cefalexin were fetermined as δd=8.3, δs=10.2 (cal/cm3)1/2 for intact cefalexin and δd=9.6, δs=12.0(cal/cm3)1/2 for the amorphous. The partial solubility parameters of intact samples were the smallest among those of different crystallinity samples. The variation of δs with crystallinity was significantly greater than that of δd. For the estimation of the interaction with water, the inveraction radii were calculated, and the effectiveness of this value was confirmed.
No takes yet. Share an insight, caveat, or question.
Egawa et al. (1992) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: