Effects of multiple training modalities in patients with Alzheimer’s disease: a pilot study

Objective: This pilot study investigated the effects of multiple training modalities on cognition, neuropsychiatric symptoms, caregivers’ burden, and quality of life in patients with Alzheimer’s disease (AD). Patients and methods: This intervention study was conducted in 24 patients with AD aged ≥65 years with a Clinical Dementia Rating (CDR) score of 0.5–1. The patients were assigned to receive multiple training modalities (1 hour for each training: Tai Chi, calligraphy, and drawing) over a 6-week period in either the experimental group (n=14) or the comparison group (n=10). A series of neuropsychological tests – namely the Traditional Chinese version Mini-Mental Status Examination, Cognitive Assessment Screening Instrument (CASI), Neuropsychiatric Inventory and the Neuropsychiatric Inventory Caregiver Distress Scale, and the Clinical Dementia Rating Sum of Boxes scale – were conducted at the baseline and after the intervention. The World Health Organization Quality of Life-BREF (WHOQOL-BREF) and Zarit Caregiver Burden Scale were used to assess the quality of life and caregivers’ burden, respectively. Independent sample t -test and paired sample t -test were used to analyze the data. Results: After the intervention, the experimental group reported higher scores in the orientation domain of CASI ( P =0.007) and in the psychiatry domain of WHOQOL-BREF ( P =0.042) compared with the comparison group. Caregivers’ distress was significantly decreased in the experimental group ( P =0.035) but not in the comparison group ( P =0.430). Conclusion: The multiple training modalities improved scores in the orientation domain of CASI and psychiatry domain of WHOQOL-BREF in patients with AD. Moreover, the intervention reduced caregivers’ distress.