Why the study?
Does alpha-tocopherol prevent adriamycin-induced cardiac toxicity in patients receiving adriamycin?
Population
Patients treated with adriamycin (median cumulative dose 550 mg/m2)
Design
Case_series
Authors
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Alpha-tocopherol cannot be endorsed for adriamycin cardioprotection from this series; leaves open whether antioxidants warrant randomized trials.
Does alpha-tocopherol prevent adriamycin-induced cardiac toxicity in patients receiving adriamycin?
High-dose oral alpha-tocopherol does not protect against adriamycin-induced cardiotoxicity, though it does not compromise the drug's antitumor efficacy.
Legha et al. (1982) studied this question.
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