Radioiodinated rabbit-anti-rat-fibrin antibodies purified by absorption and elution from rat fibrin localized in vivo, in the solid form of the Murphy rat lymphosarcoma and in three other transplantable rat tumors, like the anti-ascites-tumor antibodies purified from ascites tumor sediment. Radioiodinated rat and human fibrinogens also localized in a like manner in the lymphosarcoma but not always to the same extent. Several other antiserums, including those prepared against solid and ascites forms of the Murphy-Sturm lymphosarcoma, against ascites forms of three other rat tumors, and against human fibrinogen, contained antibodies with a cross reaction to rat fibrin, which localized in the Murphy lymphosarcoma when purified from rat fibrin. It is suggested that the type of antibody localization described was mediated through fibrinogen during its conversion to fibrin in the tumor mass. The antibody combined with fibrinogen in the circulation and was fixed with it in the tumor.
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Day et al. (1959) studied this question.