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December 1, 1999Diabetes

Decreased expression of t-SNARE, syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets: restoration of decreased t-SNARE proteins improves impaired insulin secretion.

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Authors

SNShinya NagamatsuHoward Hughes Medical InstituteYNYoko NakamichiKyorin UniversityCYChie YamamuraKyorin University

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Cite This Study

Nagamatsu et al. (1999) studied this question.

synapsesocial.com/papers/6a762e968802f13c0e614381https://doi.org/10.2337/diabetes.48.12.2367
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decreased Sensitivity of the Pancreatic Beta Cells to Glucose in Prediabetic and Diabetic Subjects: A Glucose Dose-Response Study1972 · 252 citations
  2. 2Impaired Glucose Sensitivity of ATP-Sensitive K+ Channels in Pancreatic β-cells in Streptozotocin-Induced NIDDM Rats1992 · 36 citations
  3. 3Natural History of β-Cell Dysfunction in NIDDM1990 · 248 citations