Laboratory evaluation demonstrates falsely low glycated hemoglobin readings from novel variant Hb Stockholm, highlighting analytical interference in diabetes monitoring.
A new beta-hemoglobin (Hb) variant, Hb Stockholm [beta7(A4)GluAsp], is described. The variant was characterized by mass spectrometry and DNA sequencing. The new variant is clinically silent but interferes with Hb A(1c) quantification using ion exchange chromatography, causing a falsely low Hb A(1c) level when using the Bio-Rad VARIANT II System.
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Bergman et al. (2009) studied this question.
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