published fermentation processes, showed an optimum aeration rate (table 4).At high aeration a yeast product with a relatively low lysine content, 13.2 per cent, was obtained.At low aeration, the highest lysine content, 16.5 per cent, was obtained, although the cell yield was reduced.At the lowest aeration used, both lysine content and cell growth were reduced.SUMMARY Conversion of 2-oxoadipic acid to lysine with Sac- charomyces cerevisiae was accomplished in aerated and agitated fermentors under fermentation conditions resembling those used in baker's yeast process.With this process, a yeast product containing about 16 per cent hot water-extractable lysine (calculated as hydrochloride) was obtained.The conversion efficiency of 2-oxoadipic acid to lysine was about 0.63 (weight basis) in a fermentation medium containing molasses as the sole carbon source.Most of the conversion took place during the growth period.Aeration, concentration of the added 2-oxoadipic acid, and time of precursor addition affected the lysine content and the conversion efficiency.
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Kenner et al. (1961) studied this question.
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