The use of potentiometric microsensors is demonstrated here for the first time to detect DNA hybridization. Cadmium sulfide nanocrystal labels bound on a secondary oligonucleotide are dissolved and detected with cadmium-selective microelectrodes exhibiting DNA detection limits of ca. 2 fmol in a 200 μL sample.
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Numnuam et al. (2007) studied this question.
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