Why the study?
Mutations appearing in the SARS-CoV-2 genome during human circulation could alter interactions between host RNA-binding proteins and viral RNA.
Key points are not available for this paper at this time.
Population
Genomes of various SARS-CoV-2 strains, including Alpha, Delta, and Omicron variants
Design
Genomic analysis and interaction modeling
May alter RBP interactions across variants; model is hypothesis-generating and requires experimental validation.
SARS-CoV-2 utilizes host cell RNA-binding proteins (RBPs) to carry out many steps of the infectious cycle. At the same time, a number of human RBPs are involved in antiviral immunity. During circulation in the human population, mutations that appeared in the SARS-CoV-2 genome could alter the interaction between cellular RBPs and the virus. Here, we have analyzed the genomes of various SARS-CoV-2 strains, including the Alpha, Delta and Omicron variants, and proposed a model of interactions between RBPs and SARS-CoV-2 RNA. It turned out that, despite the generally accepted opinion about the importance of the RBP‒virus interaction, since the onset of the COVID-19 pandemic there has been a gradual decrease in the affinity of RBPs for SARS-CoV-2 RNA.
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Malkova et al. (2025) studied this question.
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