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A heterogeneity in the Na+-dependent component of neutral amino acid uptake by the Ehrlich ascites tumor cell was previously shown to be best explained by a mediation by two distinct systems, System A (1) and System ASC (2,3).Because System A transports N-methyl amino acids (2, 3), whereas these analogs are blocked to reaction with System ASC, and because no other Na'-dependent component with the same
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Kilberg et al. (1981) studied this question.
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