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Thirty-one dogs were cooled down to 80°F and the ability of various pharmacologic agents to facilitate hypothermia induction was observed. 1) Chlorpromazine and the “lytic cocktail” accelerate hypothermia induction time. 2) Chlorpromazine is apparently the only effective agent in the “lytic cocktail.” 3) Chlorpromazine accelerates hypothermia induction by a central action. 4) Pentobarbital anesthesia is essential for production of the chlorpromazine effect.
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Jackson et al. (1959) studied this question.
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