Why the study?
Early detection of tissue hypoperfusion during CPB reduces organ dysfunction, but unsolved practical issues in measuring CO2 removal prevent CO2-derived variables from being widely monitored.
CO2-derived variables may offer important information on perfusion adequacy during cardiopulmonary bypass, though practical measurement issues currently limit their widespread use.
CO2-derived variables merit investigation for CPB perfusion monitoring; leaves open clinical adoption pending higher-level evidence.
Complications after cardiac surgery with cardiopulmonary bypass (CPB) are associated with increased morbidity and mortality. Early detection and prompt reversion of tissue hypoperfusion during CPB are key factors to reduce organ dysfunction after cardiac surgery. CO 2 (carbon dioxide)-derived variables which are easy to assess and routinely available to evaluate the adequacy of macro- and microcirculation may offer important information on the adequacy of the perfusion during CPB. However, since some practical issues remain unsolved in providing a reliable measurement of CO 2 removal from the patient, CO 2 -derived variables are not widely monitoring during CPB. This review aims to demonstrate the basic principles of CO 2 -derived variables during CPB, the available techniques to assess CO 2 -derived variables on CPB and the clinically relevant applications.
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Zhang et al. (2023) studied this question.
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