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June 9, 2017Science Immunology

Suppression by human FOXP3 ⁺ regulatory T cells requires FOXP3-TIP60 interactions

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Abstract

Targeting the FOXP3-TIP60 interaction may modulate T reg activity in IPEX and other autoimmune and inflammatory diseases.

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Cite This Study

Dhuban et al. (2017) studied this question.

synapsesocial.com/papers/6a7645d1ecd5a603af06dae4 https://doi.org/10.1126/sciimmunol.aai9297

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Keep reading

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

1Functional dynamics of Foxp3<sup>+</sup> regulatory T cells in mice and humansOriginal Research · 2014 · 53 citations
2Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genesOriginal Research · 2015 · 24 citations
3Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilizationOriginal Research · 2009 · 386 citations