Physical exercise modulates the homeostasis of human regulatory T cells

A sedentary lifestyle increases the risk for various medical conditions, whereas regular physical activity (PA) has been shown to promote health and reduce the risk of developing chronic disorders such as cardiovascular disease and cancer, which are prevalent in industrialized countries.1 The cellular and molecular mechanisms by which PA mediates its beneficial effects are poorly understood. Because a common etiologic factor for many noncommunicable diseases of affluence is persistent sterile inflammation, PA could exert part of its effects by dampening chronic low-grade inflammation.