Severe Neutropenia and Thrombocytopenia Associated with Infliximab

Letters5 August 2003Severe Neutropenia and Thrombocytopenia Associated with InfliximabFrancesc Vidal, MD, PhD, Ramn Fontova, MD, PhD, and Cristbal Richart, MD, PhDFrancesc Vidal, MD, PhDHospital Universitari Joan XXIII, Universitat Rovira i Virgili; 43007 Tarragona, Spain (Vidal, Fontova, Richart), Ramn Fontova, MD, PhDHospital Universitari Joan XXIII, Universitat Rovira i Virgili; 43007 Tarragona, Spain (Vidal, Fontova, Richart), and Cristbal Richart, MD, PhDHospital Universitari Joan XXIII, Universitat Rovira i Virgili; 43007 Tarragona, Spain (Vidal, Fontova, Richart)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-3-200308050-00021-w4 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Infliximab, a monoclonal antitumor necrosis factor (TNF)- antibody, has recently been approved for treatment of rheumatoid arthritis (1, 2). To date, therapy with this drug has been associated with few adverse events (3-5).Objective: To describe a patient who developed severe neutropenia and thrombocytopenia after administration of infliximab.Case Report: A 60-year-old woman had developed rheumatoid arthritis in her forties. She had received many drugs, including nonsteroidal anti-inflammatory drugs, steroids, chloroquine, cyclophosphamide, and methotrexate (up to 15 mg/wk), with good hematologic tolerance but poor clinical results. The disease progressed markedly, and by the beginning of 2001, ...References1. Lipsky PE, van der Heijde DM, St Clair EW, Furst DE, Breedveld FC, Kalden JR, . Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. N Engl J Med. 2000;343:1594-602. [PMID: 11096166] CrossrefMedlineGoogle Scholar2. Klippel JH. Biologic therapy for rheumatoid arthritis [Editorial]. 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[PMID: 11396102] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Hospital Universitari Joan XXIII, Universitat Rovira i Virgili; 43007 Tarragona, Spain (Vidal, Fontova, Richart) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRheumatoid arthritis: current therapeutics compendiumCurrent Perspectives on the Role of TNF in Hematopoiesis Using Mice With Humanization of TNF/LT SystemThe Blood in RheumatologyBiologic Disease-modifying Antirheumatic Drug (bDMARD)-induced Neutropenia: A Registry from a Retrospective Cohort of Patients with Rheumatic Diseases Treated with 3 Classes of Intravenous bDMARDCombination of infliximab with thiopurines significantly reduces white cell and neutrophil counts in inflammatory bowel disease patientsSevere Thrombocytopenia Induced by First Infliximab Administration for Rheumatoid ArthritisNeutropenia in the Elderly: A Rheumatology 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thrombocytopenia in a psoriatic patient treated with etanerceptAdverse Drug Reactions Affecting Blood CellsGLUCOCORTICOIDS AND DISEASE – MODIFYING ANTIRHEUMATIC DRUGSImmune Thrombocytopenia in Patients with Connective Tissue Disorders and the Antiphospholipid Antibody SyndromeDrug-induced immune thrombocytopenia: pathogenesis, diagnosis, and managementThrombocytopenia associated with the use of anti–tumor necrosis factor–α agents for psoriasisAddition of Infliximab to Standard Acute Graft-versus-Host Disease Prophylaxis following Allogeneic Peripheral Blood Cell TransplantationNeutropénie et thrombopénie chez un malade traité par étanercept pour un psoriasisGuidelines of care for the management of psoriasis and psoriatic arthritisEs necesario el control de la psoriasis a largo plazoFrom the Medical Board of the National Psoriasis Foundation: Monitoring and vaccinations in patients treated with biologics for psoriasisInfliximab treatment in patients with rheumatoid arthritis and 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W-63KeywordsBlood countsDrug therapyDrugsFeversGranulocytesMacrophagesMethotrexateNeutropeniaPatientsRheumatoid arthritis ePublished: 5 August 2003 Issue Published: 5 August 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. 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