Golden opportunities: A redox-, atom-, and step-economical asymmetric cascade reaction for the synthesis of chiral spirocyclic architectures with two contiguous stereocenters in high yields and excellent enantioselectivities by using a gold/chiral Brønsted acid relay catalysis system is described (see scheme). The results suggest that the chiral Brønsted acid rather than the chiral gold phosphate complex serves as the real catalyst of the enantiodetermining step.
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Qian et al. (2013) studied this question.
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