A 2½ year old patient with adrenogenital syndrome due to adrenal hyperplasia proved by biopsy and with the clinically unusual symptom of hypertension has been treated with cortisone acetate. This therapy resulted in reduction of the hypertension. The adrenogenital syndrome may be due to pituitary stimulation of the adrenal cortex. The hypertension possibly is due to compensatory zona glomerulosa changes secondary to abnormal secretion of adrenal androgens.
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Shepard et al. (1951) studied this question.
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