A gas-liquid chromatography procedure for the determination of carbenoxolone in human serum is described. The method showed a better than ± 11% coefficient of variation for all values determined. The mean determined value is accurate to ± 10% of the known value for carbenoxolone over a range of 5 to 100 μg ml−1 serum. The specificity of the method was established by combining the gas-liquid chromatography analysis with thin-layer chromatography of prepared standards and serum from treated volunteers. The method is suitable for routine pharmacokinetic and bioavailability studies of carbenoxolone in serum and other biological fluids and supersedes previous methods in specificity, sensitivity and simplicity of determination.
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Rhodes et al. (1974) studied this question.
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