Key result
Serum amyloid A spikes up to ~2200-fold following acute myocardial infarction, peaking on day 3.
Observational (n=53)
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Serum amyloid A concentrations were determined in serial serum samples of 41 patients with confirmed acute myocardial infarction (10 with acute ischaemia and two with myocarditis). A sharp increase in serum amyloid A concentration was observed early at onset of infarct; it peaked on the third day (up to 2200 fold of normal values) and declined towards normal during the following days, if no complications occurred. Different patterns were observed in patients with acute ischaemia or myocarditis. Although serum amyloid A is not a specific marker, it may, because of its high sensitivity and characteristic patterns of change, represent an additional useful biochemical variable in the diagnosis, follow up, and prognosis of acute ischaemic heart disease.
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Shainkin-Kestenbaum et al. (1986) conducted an observational in Acute ischaemic heart disease (acute myocardial infarction, acute ischaemia, or myocarditis) (n=53). Serum amyloid A concentration measurement vs. Patients with acute ischaemia or myocarditis / normal values was evaluated on Serial serum amyloid A concentration patterns. Serum amyloid A concentrations increased sharply after acute myocardial infarction, peaking on day 3 at up to 2200-fold of normal values before declining.
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