A marked enhancement of X-ray-induced DNA double-strand breakage was demonstrated for mitotic Chinese hamster (V79) cells compared with S-phase cells or asynchronous cultures, which can explain the high radiosensitivity of mitotic cells. However, mitotic cells required twice the level of DNA double-strand breakage to produce a lethal lesion of that required for S-phase or asynchronous cells, suggesting that repair in mitotic cells is less error prone.
No takes yet. Share an insight, caveat, or question.
Radford et al. (1986) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: