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May 1, 1986Canadian Journal of Neurological Sciences / Journal Canadien des Sciences NeurologiquesOpen Access

Nemaline Myopathy in an Adult with Primary Hypothyroidism

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Population

A 50-year-old black woman with primary hypothyroidism, congestive heart failure, pericardial effusion, and…

Design

Case_report

Follow-up

Approximately 3 months

Authors

MRMarcelino G. ReyesUnited States Department of Veterans AffairsATAlexander TalTruman Medical CenterDADavid AbrahamsonParsons (United States)

Discussion

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Overview

This case report highlights the rare coexistence of primary hypothyroidism and adult-onset nemaline myopathy in a patient presenting with congestive heart failure and pericardial effusion.

Structured PICO

P
Population
A 50-year-old black woman with primary hypothyroidism, congestive heart failure, pericardial effusion, and generalized weakness (n=1).
I
Intervention
L-thyroxine, digoxin, furosemide, and partial pericardiectomy
O
Outcome
Clinical course and muscle biopsy findings

This case report highlights the rare coexistence of primary hypothyroidism and adult-onset nemaline myopathy in a patient presenting with congestive heart failure and pericardial effusion.

Limitations

  • No autopsy performed
  • Myocardium not biopsied to confirm nemaline cardiomyopathy

Cite This Study

Reyes et al. (1986) studied this question.

synapsesocial.com/papers/6a7650741f441c00d3bcb615https://doi.org/10.1017/s0317167100036039
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nemaline Myopathy Appearing in Adults as Cardiomyopathy1984 · 53 citations
  2. 2Congenital nemaline myopathy. I. Defective organization of α‐actinin is restricted to muscle1983 · 27 citations
  3. 3The Thyroid and Its Diseases1964 · 691 citations
  4. 4Pathology of Skeletal Muscle.1985 · 282 citations
  5. 5Muscle fibre type changes in hypothyroid myopathy.1975 · 88 citations