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Very uncommon within the plants, palmitoleic acid (POA) is present in high amount in the oil obtained from the pulp of the sea buckthorn (SB). Although POA was shown to exert anti-diabetic effects when used separately, more studies are needed to certify the application of POA present in SB oil. We show that the potency of SB pulp oil to augment glucose-induced insulin secretion has been associated with activation of G protein-coupled receptors present in pancreatic β-cells. The activity was shown in digested SB oils suggesting that released from triacylglycerols free fatty acid act as the active components. Among all fatty acids present in SB pulp oil POA demonstrated the highest activity. Analysis of five variants of SB oil samples prepared with different extraction methods revealed that the unsaponifiable compounds do not exert the synergic effect with the fatty acids.
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Korkus et al. (2022) studied this question.
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