Safety and Efficacy of Long-term Diazepam Therapy

Clinical evidence of withdrawal phenomena and efficacy was studied in 23 long-term users of diazepam (15 to 50 mg daily). No withdrawal reactions were observed in the ten patients who received placebo in a double-blind fashion for a two-week period. Changes in anxiety scores of both patients who received placebo and those who received diazepam suggest that the diazepam continued to be effective when used for one year or longer.