Copper-free cycloaddition of azide and alkyne in crystalline state facilitated by arene–perfluoroarene interactions

Facilitated by arene-perfluoroarene interactions, a 1,3-dipolar cycloaddition between azide and alkyne proceeded in the crystals at room temperature in the absence of a copper(I) catalyst, and the reaction was confirmed to be a highly regioselective process giving the 1,4-triazole product.