A sustained hypernatremia associated with chronic nonspecific inflammatory change of the neurohypophysis has not hitherto been described. A case of a 66-yr-old woman who showed hypernatremia and clinical manifestations of dehydration of 1 month's duration is reported. She had hypodipsia and impairment of urine concentration. Hypernatremia and dehydration were successfully treated with Pitressin Tannate. Autopsy findings revealed a marked fibrosis and infiltration of lymphocytes and plasma cells confined to the neurohypophysis. It was concluded that the hypernatremia was induced by hypodipsia and the deficiency of release of antidiuretic hormone from the neurohypophysis was due to chronic inflammatory change.
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Saito et al. (1970) studied this question.