Synthetic study demonstrates efficient direct generation of N,O-acetals via hypervalent iodine-mediated oxidative fragmentation, indicating an improved route toward key discorhabdin intermediates.
The use of hypervalent iodine(III) reagents allowed us to develop the novel and efficient direct synthesis of N,O-acetal compounds via the oxidative fragmentation reaction of alpha-amino acids or alpha-amino alcohols; furthermore, we succeeded in developing an improved synthesis of the key intermediate of discorhabdins.
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Harayama et al. (2005) studied this question.
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