Key result
Prostaglandin E1 binds HDL with high affinity and induces surface lipid rearrangement.
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Prostaglandin E1 has been shown to interact with serum high density lipoproteins (HDL) in a manner resembling the interaction of a ligand with a high affinity binding site. The presence of 10(-12)-10(-10) M prostaglandin E1 induces a rearrangement of the HDL surface lipids and probably influences the biological functions of the lipoproteins.
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Manevich et al. (1984) studied this question. Prostaglandin E1 (10^-12 to 10^-10 M) binds to human serum HDL with high affinity and induces a rearrangement of HDL surface lipids.
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