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A high-profile experiment using gene therapy to treat hemophilia B has been on hold for 3 months because of concerns that it might alter the inheritable, or “germ line,” DNA of patients in the trial. Last week, those concerns got their first public airing at a meeting of the Recombinant DNA Advisory Committee (RAC) of the National Institutes of Health. The session did not yield a clear decision, but several panel members indicated that they thought the research should be allowed to resume.
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Eliot Marshall (2001) studied this question.