Why the study?
The study aimed to evaluate and compare the impact of laparoscopic sleeve gastrectomy and one anastomosis gastric bypass on renal function and urinary monocyte chemoattractant protein-1 levels in morbidly obese patients.
Does laparoscopic sleeve gastrectomy compared to one anastomosis gastric bypass improve renal function and urinary MCP-1 levels in morbidly obese patients?
Does laparoscopic sleeve gastrectomy compared to one anastomosis gastric bypass improve renal function and urinary MCP-1 levels in morbidly obese patients?
Both laparoscopic sleeve gastrectomy and one anastomosis gastric bypass similarly improve renal function and reduce urinary MCP-1 levels in morbidly obese patients at 3 months post-surgery.
Both surgeries associated with short-term renal improvement and MCP-1 reduction; leaves open differential long-term effects between LSG and OAGB.
INTRODUCTION: Bariatric surgery has been the most effective treatment modality for morbid obesity that reduces associated comorbidities and improves quality of life. This study aims at evaluating and comparing the impact of two types of bariatric surgery-laparoscopic sleeve gastrectomy (LSG) and one anastomosis gastric bypass (OAGB)-on renal functions and urinary monocyte chemoattractant protein-1 (MPC-1) levels in morbidly obese patients 3 months after surgery. METHODS: This is a prospective study of 40 morbidly obese patients who underwent bariatric surgery. Two types of bariatric surgery were done-laparoscopic sleeve gastrectomy (LSG) (26 patients) and laparoscopic one anastomosis gastric bypass (OAGB) (14 patients). The outcomes of the two procedures were compared in terms of renal function parameters and the level of urinary MCP-1. RESULTS: There were no statistically significant differences in the mean postoperative urinary MCP-1 (73.53 ± 21.25, 75.43 ± 26.17, P > 0.5), microalbuminuria (8.83 ± 6.26, 10.02 ± 8.6, P > 0.05), urinary creatinine (109.21 ± 43.22, 99.19 ± 48.65, P > 0.05), MCP1/Cr ratio (0.78 ± 0.36, 1.01 ± 0.70, P > 0.05), eGFR (100.32 ± 9.54, 104.39 ± 9.54, P > 0.05) in the cases who had either LSG operation or OAGB operation. CONCLUSION: Bariatric surgery improves all indicators of kidney malfunction and reduces the level of urinary MCP-1. Both laparoscopic sleeve gastrectomy (LSG) and laparoscopic one anastomosis gastric bypass (OAGB) cause similar improvement of the renal function and reduction of urinary MCP-1 level.
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Elmamlook et al. (2024) studied this question.
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