Box isolation of the posterior left atrium can unmask unidirectional pulmonary vein reconnection even when entrance and exit blocks were previously confirmed.
May miss unidirectional PV reconnections with entrance block alone; leaves open optimal bidirectional testing protocols.
The endpoint of pulmonary vein (PV) isolation of atrial fibrillation (AF) is to achieve bidirectional conduction block between the PVs and left atrium (LA), which is indicated both by the elimination or dissociation of the PV potentials during sinus rhythm or atrial pacing (entrance block) and failure to capture the atria by pacing from the PVs (exit block).1 We present a case with a unidirectional reconnection from the LA to the right-sided PVs (RPVs), which was unmasked during a box isolation (BOXI) of the posterior LA, even though both entrance and exit block of the RPVs were confirmed before the BOXI, in a patient undergoing a second ablation procedure for recurrent AF.
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Nakamura et al. (2020) studied this question.
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