Why the study?
To test the hypothesis that a particular immune activation profile might be correlated with insulin resistance in a general population.
Is a specific immune activation profile associated with insulin resistance in a general population?
Is a specific immune activation profile associated with insulin resistance in a general population?
A specific immune activation profile characterized by CD4+ T cell senescence and inflammation is associated with markers of insulin resistance and metabolic syndrome.
May link immune profiles to metabolic risk; hypothesis-generating and requires prospective validation before clinical consideration.
We tested the hypothesis that a particular immune activation profile might be correlated with insulin resistance in a general population. By measuring 43 markers of immune, endothelial, and coagulation activation, we have previously shown that five different immune activation profiles may be distinguished in 150 volunteers. One of these profiles, Profile 2, characterized by CD4+ T cell senescence, inflammation, monocyte, B cell, and endothelial activation, presented elevated insulinemia, glycemia, triglyceridemia, and γ-glutamyl transferase, a marker of liver injury, in comparison with other profiles. Our data are compatible with a model in which a particular immune activation profile might favor the development of insulin resistance and metabolic syndrome. In this hypothesis, identification of this profile, that is feasible with only 3 markers with an error rate of 5%, might allow to personalize the screening and prevention of metabolic syndrome-driven morbidities as liver steatosis.
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Cezar et al. (2021) studied this question.
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