Autoinflammation and autoimmunity in systemic juvenile idiopathic arthritis

This is the authors' abstract. We don't add key points for this paper.

Juvenile idiopathic arthritis (JIA) encompasses a range of phenotypes of joint inflammation that begin in childhood.The most distinctive and potentially most severe of these is systemic JIA (sJIA), an intensely inflammatory disease characterized by high spiking fevers and evanescent rashes that sometimes progresses to a devastating chronic polyarthritis.In PNAS, Ombrello et al. establish an unequivocal genetic association between sJIA and the major histocompatibility (MHC) region, in particular with the class II allele HLA-DRB1*11 (1).This is a big deal.Let's consider why.