In Vitro and In Vivo Characterization of Tebipenem, an Orally Active Carbapenem, against Biothreat Pathogens

This is the authors' abstract. We don't add key points for this paper.

Bacillus anthracis and Yersinia pestis , the causative pathogens for anthrax and plague, respectively, along with Burkholderia mallei and Burkholderia pseudomallei are potential bioterrorism threats. Tebipenem pivoxil hydrobromide (TBP HBr) (formerly SPR994) is an orally available prodrug of tebipenem, a carbapenem with activity versus multidrug-resistant (MDR) Gram-negative pathogens, including quinolone-resistant and extended-spectrum-β-lactamase-producing Enterobacterales .