Why the study?
Does the Ca-induced Ca release mechanism differ in skeletal muscle from a patient with malignant hyperthermia compared to normal muscle?
Does the Ca-induced Ca release mechanism differ in skeletal muscle from a patient with malignant hyperthermia compared to normal muscle?
The study identifies heightened sensitivity and maximum rate of Ca-induced Ca release in the sarcoplasmic reticulum as the likely underlying mechanism for malignant hyperthermia.
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Supports Ca release hypersensitivity as MH mechanism; leaves open translation to human therapies.
Endo et al. (1983) studied this question.
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