Key result
Bacteremia reliably induces infective endocarditis and glomerulonephritis in canine aortic insufficiency models.
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Following the induction of aortic insufficiency, 15 dogs received intravenous injections of either Staphylococcus aureus or Streptococcus mitis . The clinical course and pathologic picture resembled those of acute and subacute bacterial endocarditis respectively. The valvular lesions were confined largely to contacting surfaces of aortic and mitral leaflets. The dogs given S. mitis often developed an acute diffuse proliferative glomerulonephritis. No such valvular or renal lesions were noted in 10 control dogs, including 2 with sham operations, given similar bacterial injections.
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Highman et al. (1956) studied Experimental bacterial endocarditis and aortic insufficiency (n=25). Intravenous injection of Staphylococcus aureus or Streptococcus mitis following aortic insufficiency induction vs. Control dogs without aortic insufficiency (including 2 sham-operated dogs) given similar bacterial injections was evaluated on Development of bacterial endocarditis (valvular lesions) and renal lesions (acute diffuse proliferative glomerulonephritis). IV injection of S. aureus or S. mitis in 15 dogs with induced aortic insufficiency produced bacterial endocarditis and renal lesions vs 0% in 10 controls.
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