Cardiac Amyloidosis

Case Reports1 December 1961Cardiac AmyloidosisTwo Cases with Digitalis SensitivityJAMES T. CASSIDY, M.D.JAMES T. CASSIDY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-6-989 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGeneralized Amyloidosis is an uncommon disorder; the approximate frequency at autopsy is 0.5%. It is, however, a subject of frequent diagnostic consideration because of its diversified clinical manifestations. The heart is affected to a significant degree in 40 to 90% of cases (1-4). Such involvement was responsible for major disability in two patients, one with primary amyloidosis, the other with amyloidosis secondary to plasmacytoma. Observations in these cases which might suggest amyloid infiltration as a cause for obscure heart disease are discussed, with particular attention to a previously unreported sensitivity to digitalis.CASE REPORTSCASE 1A 58-year-old farmer was...References1. SYMMERS WS: Primary amyloidosis: a review. J. Clin. Path. 9: 187, 1956. CrossrefMedlineGoogle Scholar2. RUKAVINABLOCKJACKSONFALLSCAREYCURTIS JGWDCEHFJHAC: Primary systemic amyloidosis: a review and an experimental, genetic, and clinical study of 29 cases with particular emphasis on the familial form. Medicine 35: 239, 1956. CrossrefMedlineGoogle Scholar3. BUERGERBRAUNSTEIN LH: Senile cardiac amyloidosis. Amer. J. Med. 28: 357, 1960. CrossrefMedlineGoogle Scholar4. DAHLIN DC: Secondary amyloidosis. Ann. Intern Med. 31: 105, 1949. LinkGoogle Scholar5. SANDERSCHILD RJCG: Primary amyloidosis with jaundice. J. A. M. A. 174: 1202, 1960. CrossrefMedlineGoogle Scholar6. WOLLAEGER EE: Primary systemic amyloidosis with symptoms and signs of liver disease; diagnosis by liver biopsy. Med. Clin. N. Amer. 34: 1113, 1950. CrossrefMedlineGoogle Scholar7. CALKINSCOHEN EAS: Amyloidosis, in Arthritis and Allied Conditions, 6th Ed., ed. by Hollander, J. L., Lea & Febiger, Philadelphia, 1960, pp. 1011-25. Google Scholar8. WEISS S: Diseases of the heart and the aorta which are not well recognized. Med. Clin. N. Amer. 23: 1323, 1939. CrossrefGoogle Scholar9. CALKINSCOHEN EAS: Diagnosis of amyloidosis. Bull. Rheum. Dis. 10: 215, 1960. MedlineGoogle Scholar10. VASSARCULLING PSCF: Fluorescent stains, with special reference to amyloid and connective tissue. Arch. Path. 68: 487, 1959. MedlineGoogle Scholar11. MULLIGAN RM: Amyloidosis of the heart. Arch. Path. 65: 615, 1958. MedlineGoogle Scholar12. BALLINGER J: Amyloid heart disease. Amer. J. Med. Sci. 217: 308, 1949. CrossrefMedlineGoogle Scholar13. FINDLEYADAMS JWW: Primary systemic amyloidosis simulating constrictive pericarditis. Arch. Intern. Med. 81: 342, 1948. CrossrefGoogle Scholar14. GUNNARDILLONWALLYNELISBERG RMRFRJEI: The physiologic and clinical similarity between primary amyloid of the heart and constrictive pericarditis. Circulation 12: 827, 1955. CrossrefMedlineGoogle Scholar15. ELIOTMCGEEBLOUNT RSHJSG: Cardiac amyloidosis. Circulation 23: 613, 1961. CrossrefGoogle Scholar16. LOWNLEVINE BSA: Current concepts in digitalis therapy. New Engl. J. Med. 250: 771; and 250: 819, 1954. CrossrefMedlineGoogle Scholar17. SILBER EN: Respiratory viruses and heart disease. Ann. Intern. Med. 48: 228, 1958. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, MichiganFrom the Department of Internal Medicine, University Hospital, Ann Arbor, Michigan.Requests for reprints should be addressed to James T. Cassidy, M.D., Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan. 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JAMES, M.D., F.A.C.P.Digitalis-induced arrhythmias and their managementThe pathology of senile cardiac amyloidosisSenile cardiac amyloidosis.Störungen des ProteinstoffwechselsThe clinical spectrum of primary myocardial diseaseAmyloid heart diseaseClinical manifestations of cardiac amyloidosis 1 December 1961Volume 55, Issue 6Page: 989-994KeywordsAmyloidosisArrhythmiaArthritisAutopsyCardiovascular therapyDisabilitiesElectrocardiographyHeartHospital medicine Issue Published: 1 December 1961 PDF DownloadLoading ...