Summary: Natural killer (NK) cells express two types of receptors involved in target recognition: inhibitory receptors for target cell MHC class I molecules and activation receptors. While there has been significant progress in understanding the inhibitory receptors, less is known about the activation receptors. Detailed analysis of several mouse NK‐cell activation receptors provides insight into the physiologic relevance of these receptors in the innate immune response. We gratefully acknowledge past and present members of our laboratory for their work on NK‐cell receptors and particularly Hubert Chuang for his recent efforts on Qa‐1 receptors mentioned in this manuscript. Work in the Yokoyama laboratory is supported by grants from the National Institutes of Health. H.R.C.S. is supported by a training grant from NIH. W.M.Y. is an investigator of the Howard Hughes Medical Institute.
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Smith et al. (2001) studied this question.