This review highlights the pathophysiological links between chronic renal insufficiency and cardiovascular disease, emphasizing the prognostic value of eGFR and microalbuminuria.
Chronic renal insufficiency and atherosclerosis are tightly connected clinical syndromes. Overall, renal function assessed by estimated glomerular filtration rate correlates with total and cardiovascular mortality in a graded fashion. In addition, microalbuminuria is a prognostic indicator for both progression of chronic renal insufficiency and adverse cardiovascular outcomes. Chronic renal insufficiency related neurohumoral stimulation, including the renin–angiotensin-aldosterone system and the sympathetic nervous system is focused on, therapeutic implications are provided. In addition, the role of systemic inflammation with respect to endothelial function, vascular calcification and metabolism is highlighted. This review aims to summarize recent research results concerning chronic renal insufficiency pathomechanisms relevant to cardiovascular disease.
No takes yet. Share an insight, caveat, or question.
Rainer U. Pliquett (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: