Key result
Intensive statin therapy is linked to an ~19% reduction in high-intensity plaque signal intensity.
Why the study?
Does intensive pitavastatin treatment reduce the plaque-to-myocardium signal-intensity ratio (PMR) of coronary high-intensity plaques in patients with coronary artery disease?
Cohort (n=96)
Does intensive pitavastatin treatment reduce the plaque-to-myocardium signal-intensity ratio (PMR) of coronary high-intensity plaques in patients with coronary artery disease?
p-value: p=<0.001
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Intensive statin therapy significantly reduces the plaque-to-myocardium signal-intensity ratio of high-intensity coronary plaques, suggesting a reduction in plaque vulnerability.
Noguchi et al. (2015) conducted a cohort in Coronary artery disease (n=96). Intensive statin therapy (pitavastatin) vs. No statin treatment was evaluated on 12-month change in plaque-to-myocardium signal-intensity ratio (PMR) (p=<0.001). Intensive statin therapy significantly reduced the plaque-to-myocardium signal-intensity ratio of high-intensity plaques by 18.9% (P<0.001), compared to a 19.2% increase in matched controls.
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