Cbfβ governs osteoblast−adipocyte lineage commitment through enhancing β-catenin signaling and suppressing adipogenesis gene expression

Significance Age-associated increased marrow adiposity is often coupled with increased bone loss, presenting a significant age-associated osteoporosis health problem. Here, we examined the mechanisms underlying how transcription factors regulate mesenchymal stem cell lineage determination and showed that Cbfβ plays a critical role in stimulating osteogenesis and inhibiting adipogenesis through activating Wnt10b/β-catenin signaling and inhibiting adipogenesis regulatory gene ( c/ebpα ) expression. The insights resulting from this study will fill an important knowledge gap and may facilitate the development of novel bone loss therapeutics that minimize the adverse side effects on bone homeostasis.