We previously reported that the infusion of ex vivo expanded umbilical cord blood (UCB)-derived natural regulatory T cells (nTregs) infused immediately after UCB transplantation was associated with a reduced incidence of acute graft-versus-host disease (GVHD) relative to historical control subjects [1]. We did not observe an increased incidence of opportunistic infections or relapse, suggesting the transient nature of nTreg provided sufficient immune suppression to control GVHD without long-term deleterious effects.
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Brunstein et al. (2013) studied this question.
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